Ham and Cheese Bisquick Breakfast Casserole Recipe

Bisquick Breakfast Casserole recipe is a delightful morning dish that’s ideal for special occasions or a relaxed weekend brunch. This hearty casserole balances savory flavors and tender texture, making it an easy way to serve a memorable breakfast for family and friends.

If you enjoy this casserole, you might also like Bisquick sausage balls for another quick and satisfying breakfast option.

A pie cutter is holding a piece of the bisquick breakfast casserole over the casserole dish.

This recipe is perfect when you want something special without standing at the griddle. It’s straightforward to assemble and delivers big flavor with minimal effort.

Keeping Bisquick or pancake mix on hand is a great pantry shortcut. It works in many recipes beyond pancakes: from pot pies and cookies to waffles and cinnamon rolls. This breakfast casserole is a versatile way to use that mix for a savory meal.

Why You’ll Love This Recipe

  • Simple to prepare. No flipping or individual cooking required—just mix the ingredients in one bowl and bake.
  • Uses common pantry staples. Bisquick, eggs, milk, cheese, and ham make this an easy recipe with ingredients you likely already have.
  • Make-ahead friendly. Assemble the casserole, refrigerate overnight, then bake when ready—perfect for holidays or busy mornings.
  • Feeds a crowd. The recipe scales easily for large gatherings—use a sheet pan for a bigger batch and serve alongside other brunch favorites.

Ingredients to Gather

Gather a handful of simple ingredients to make this satisfying breakfast casserole.

The bisquick breakfast casserole ingredients are labeled.
  • Bisquick Pancake Mix. A time-saving blend of flour, salt, sugar, and leavening. You can use store-bought Bisquick or a homemade mix.
  • Melted butter. Adds flavor and helps keep the casserole tender. Substitute vegetable, canola, avocado, or coconut oil if preferred.
  • Ham. Thick-cut or leftover ham, chopped into bite-sized pieces.
  • Milk. Whole milk, 2%, or any milk you prefer.
  • Cheese. Shredded cheddar, Monterey Jack, or your favorite melting cheese.

See the printable recipe card below for exact quantities.

Step By Step Instructions

The bisquick and melted butter are added to a large bowl.
Step 1: Preheat oven to 375°F. Grease a 9×13-inch baking dish with butter or cooking spray. In a large bowl, combine the Bisquick and melted butter.
The eggs are added to the large mixing bowl.
Step 2: Add the eggs, milk, and mix until combined.
The seasonings are added to the large bowl.
Step 3: Stir in Italian seasoning and garlic powder for depth of flavor.
The ham is added to the large mixing bowl.
Step 4: Fold in chopped ham.
The cheese is added to the large mixing bowl.
Step 5: Gently fold in the shredded cheese.
The batter is added to a baking dish.
Step 6: Pour the batter into the prepared baking dish and bake 25–30 minutes until golden and set. Let cool 10–15 minutes before slicing and serving.

Variations

  • Add vegetables. Stir in bell peppers, onions, mushrooms, or other favorite veggies for extra color and nutrition.
  • Sweet version. Swap savory fillings for chocolate chips, vanilla, or blueberries, or bake plain and serve with pancake toppings and syrup.
  • Swap the meat. Replace ham with breakfast sausage, cooked bacon, or turkey bacon.
  • Try different cheeses. Colby Jack, Monterey Jack, or any melting cheese will work well.

How to Serve Bisquick Breakfast Casserole

  • With maple syrup. A drizzle of syrup adds a pleasant sweet contrast to the savory casserole.
  • With fresh fruit. Serve with berries or a simple fruit salad to brighten the plate.
  • As part of a brunch. Add orange juice, hash browns, scones, bagels, or a French toast casserole for a full spread.
The texture of the Bisquick Breakfast Casserole is on a fork.

Storage Tips

To prepare ahead, mix ingredients and place them in a greased baking dish. Cover and refrigerate up to 24 hours, then top with extra cheese and bake when ready.

Store leftovers in an airtight container in the refrigerator for up to 4 days. Reheat in an oven-safe dish for 10–15 minutes until warmed through.

To freeze, cut the cooled casserole into portions, place in freezer bags, and freeze up to 3 months. Reheat from frozen in the oven at a moderate temperature until heated through, about 15–20 minutes.

Frequently Asked Questions

Can I use another type of pancake mix?

Yes. If you have a homemade Bisquick substitute or a different pancake mix, it will work in this casserole.

Can I make this gluten free?

Yes. Use a certified gluten-free pancake mix to make a gluten-free version.

More Bisquick Recipes

  • Zucchini Casserole (With Bisquick!)
  • Bisquick Blueberry Bread
  • Easy Banana Pancakes with Bisquick
  • Double Chocolate Pancakes with Pancake Mix

Did you make this recipe and love it?

If so, please leave a 5-star review and comment below. Share your photo on social media and tag @Lynn’sWayofLife or use #lynnswayoflife to show your creation.

📖 Recipe

A pie cutter is holding a piece of the bisquick breakfast casserole over the casserole dish.

Bisquick Breakfast Casserole (With Ham and Cheese)

Enjoy a savory, easy-to-make breakfast casserole that combines the convenience of Bisquick with ham, cheese, and simple seasonings for a satisfying morning meal.
5 from 38 votes
Course: Breakfast
Cuisine: American
Prep Time: 5 minutes
Cook Time: 25 minutes
Total Time: 30 minutes
Servings: 12 Servings
Calories: 300kcal
Author: Lynn Polito

Equipment

  • Baking Dish
  • Measuring Cups
  • Measuring Spoons
  • Cutting Board
  • Knives
  • Wooden Spoon

Ingredients

  • 1 ½ cups Bisquick Pancake Mix
  • ½ cup Melted Butter
  • 1 cup Milk (whole, 2%, or your choice)
  • 4 Eggs
  • 2 cups Ham, chopped
  • 2 cups Cheddar Cheese, shredded
  • 1 tsp Italian Seasoning
  • 1 tsp Garlic Powder

Instructions

  • Preheat the oven to 375°F. Grease a 9×13-inch casserole dish and set aside.
  • In a large bowl, combine Bisquick, melted butter, milk, and eggs. Mix until smooth.
  • Stir in Italian seasoning and garlic powder, then mix in the chopped ham and shredded cheese until evenly distributed.
  • Pour the batter into the prepared dish. Bake 25–30 minutes, until golden and set. Let cool 10–15 minutes, then slice and serve.

Notes

  • Add veggies: Bell peppers, onions, or mushrooms are delicious additions.
  • Change the meat: Try breakfast sausage, cooked bacon, or turkey bacon instead of ham.
  • Change the cheese: Colby Jack, Monterey Jack, or another favorite melting cheese will work well.
  • Serve with maple syrup, fresh fruit, or other brunch sides.
Calories: 300 kcal
| Carbohydrates: 11 g
| Protein: 13 g
| Fat: 22 g

Nutrition information is an estimate and not guaranteed.

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